Promethazine hydrochloride and codeine phosphate syrup is indicated for the momentary aid of coughs and higher respiratory symptoms related with allergy or perhaps the typical chilly.
Promethazine is really an H1 receptor blocking agent. As well as its antihistaminic motion, it provides clinically valuable sedative and antiemetic effects.
Such as, a lot of described circumstances of death transpired while in the put up-operative interval adhering to tonsillectomy and/or adenoidectomy, and several of the kids experienced proof of getting ultra-speedy metabolizers of codeine. Additionally, little ones with obstructive rest apnea who're dealt with with codeine for put up-tonsillectomy and/or adenoidectomy discomfort might be specifically delicate to its respiratory depressant influence. Because of the hazard of existence-threatening respiratory despair and Dying:
Drug interactions could modify how your remedies work or improve your threat for really serious Unintended effects. This document doesn't include all achievable drug interactions.
Because of the possible for promethazine to reverse epinephrine’s vasopressor outcome, epinephrine shouldn't be made use of to deal with hypotension linked with promethazine overdose.
The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are complicated.
Promethazine hydrochloride was not mutagenic from the in vitro bacterial reverse mutation assay or clastogenic while in the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.
three) and Warnings and Precautions ( 5.1) ]. Bodily dependence, the ailment during which ongoing administration of your drug is required to stop the looks of the withdrawal syndrome, assumes clinically major proportions only following numerous months of ongoing oral opioid use, Though some mild degree of Bodily dependence may well develop after a couple of days of opioid therapy.
Promethazine Promethazine is really a phenothiazine spinoff, which differs structurally in the antipsychotic phenothiazines through the presence of a branched facet chain and no ring substitution.
Hardly ever share opioid medication with A different man or woman, especially someone with a record of drug abuse or dependancy. MISUSE Might cause Habit, OVERDOSE, OR Dying. Keep the medication in a location the place Other individuals are unable to get to it. Promoting or giving away opioid drugs is towards the regulation.
Promethazine with Codeine Oral Option is contraindicated for all youngsters younger than 12 a long time of age [see Contraindications ( four) ]. Promethazine with Codeine Oral Remedy is contraindicated for submit-operative management in pediatric patients young than 18 decades of age pursuing tonsillectomy and/or adenoidectomy [see Contraindications ( 4) ]. Keep away from the use of Promethazine with Codeine Oral Option in adolescents 12 to eighteen years of age who have other hazard variables that could raise their sensitivity towards the respiratory depressant outcomes of codeine unless the benefits outweigh the threats.
Therapy of Overdose Procedure of overdosage is pushed by the overall medical presentation, and includes discontinuation of Promethazine with Codeine Oral Alternative jointly with institution of appropriate therapy. Give Key focus to the reestablishment of enough respiratory exchange by provision of a patent and protected airway plus the institution of assisted or managed air flow.
Just take this medication by mouth with or without foods as directed by your health practitioner, ordinarily each individual 4 to six several hours as essential. This medication might be taken with foods if stomach upset takes place. Consume a good amount of fluids once you use this medication Unless of course otherwise directed by your doctor.
Study the Medication Guidebook supplied by your pharmacist Before you begin getting codeine/promethazine and every time you obtain a refill. When you've website got any thoughts, talk to your doctor or pharmacist.